Low-Dose Naltrexone Prescribed for Pain and Inflammation

May 19, 2021

LDN Treatment for Autoimmune Diseases

By: Lucy Casey, Content Marketing Manager, Valor Compounding Pharmacy

What is Low-Dose Naltrexone?

The Science Behind Low-Dose Naltrexone:

The FDA initially approved naltrexone in 1984 for addiction treatment. Naltrexone works by blocking opioid receptors, an active player in your brain’s “feel-good” region of the brain. Low-dose naltrexone, or LDN, has shown to work with the body’s opioid receptors instead of blocking them, leading to off-label use for anti-inflammatory effects on the body. During the study, LDN was found to increase endorphin production and analgesic effects in the patients that took naltrexone at low doses. LDN may allow the immune system to be activated by increasing endorphin levels, assisting in the clearing of auto-immune disorder-related inflammation.

Who Should Take LDN?

LDN is recommended for use in reducing the severity of symptoms associated with conditions like fibromyalgia, Crohn’s disease, multiple sclerosis, and other chronic pain conditions. Low-dose naltrexone has been evaluated as a daily oral therapy and may be the solution to patients’ needs who may not tolerate or prefer commercially available anti-inflammatory medications. With no narcotic effect, research has found that LDN causes your brain to release naturally occurring endorphins.

 

Chronic inflammation, and diseases associated with the condition, impact a significant proportion of the US population. Some environmental factors that may increase the risk of chronic inflammation include:
  • older age
  • obesity
  • smoking
  • stress
  • sleep problems
Some diseases that may include chronic inflammation as an associated risk include:
  • asthma
  • periodontitis
  • Crohn’s disease
  • active hepatitis
  • allergies
  • auto-immune disorders (like Type 1 diabetes, Hashimoto’s thyroiditis, and rheumatoid arthritis, to name a few)

What does LDN treat?

Low-dose naltrexone has been reported as effective for a variety of conditions. Including: 
    • Anxiety
    • Chronic fatigue
    • Chronic pain
    • Crohn’s disease
    • Depression
    • Dermatologic conditions
    • Female hormone regulation
    • Fibromyalgia
    • Inflammatory bowel conditions
    • Multiple sclerosis
    • Neuromuscular conditions
    • Thyroid disorders
    • Weight loss*
 Why can LDN work for such a variety of conditions? LDN works in your body, with your immune system, by boosting endorphins. The therapeutic effects of LDN may include better mood, reduction of pain² ³, and experiencing less fatigue

 

LDN Compounded by Valor

Valor™ customizes your LDN compound based on your prescription. Finding the right dose of LDN for your condition may take time, and Valor can compound your customized medication to match your journey. The most common strengths of LDN we compound are 4.5mg and 5mg. Our low pricing based on the day supply you need makes it easy for your prescription to be adjusted by your prescriber to help you find the right balance.

Day Supply* Price Shipping
30-day supply $50.00 Includes free 2-day shipping
60-day supply $85.00 Includes free 2-day shipping
90-day supply $120.00 Includes free 2-day shipping

*Prices may vary based on larger quantities needed for a 30-day supply due to tapering dose.

  • If you are currently under the care of a physician and are a new patient to Valor™, simply call (510) 548-8777 to transfer your prescription, or you may submit your transfer online via our secure form.
  • Interested in starting LDN treatment and would like a physician referral in your area? Please call (510) 548-8777 to speak with a pharmacist.
  • If you are a current Valor™ patient, you may call or submit your refill online via our secure form. Request to have your prescription auto-refill on a regular schedule and we will proactively speak with your physician for you each time.​

Contact Us

Valor Compounding Pharmacy™, Inc. is a multi-state licensed 503A facility housing both sterile and non-sterile laboratories, located in Berkeley, CA. Valor is a specialized pharmacy that makes custom medications to meet the unique needs of the individual patient. Our goal is to reinvent pharmacy from a reactive vendor to a proactive partner in patient health care. We do that by optimizing turnaround time, being data-driven, and reducing patient anxiety.

Our focus is on non-sterile and sterile, hazardous and non-hazardous compounded medication, and we work with a network of providers, patients, health systems/institutions, and research scientists in multiple states in the United States, including Alaska, Arizona, California, Colorado, Florida, Georgia, Hawaii, Maryland, Minnesota, New Mexico, New York, Oregon, Virginia, Washington, Washington, D.C., West Virginia, and Wyoming.

 

Article References:

Watson, S. (2019, March 26). “Autoimmune Diseases: Types, Symptoms, Causes, and More.https://www.healthline.com/health/autoimmune-disorders

Donahue, R. et al. (2011, July 10). “Low-dose naltrexone suppresses ovarian cancer and exhibits enhanced inhibition in combination with cisplatin.https://journals.sagepub.com/doi/abs/10.1258/ebm.2011.011096